Michalk D, Klare B, Manz F, Schärer K
Clin Nephrol. 1981 Jul;16(1):8-12.
Plasma sulfate concentration (SO4) was determined in 38 non-dialyzed children with chronic kidney disease and compared to inulin clearance and to other parameters of renal function. SO4 was measured by atomic absorption spectrophotometry. Plasma SO4 was inversely correlated with GFR and effective renal plasma flow. Positive correlations were found between plasma SO4, BUN, serum creatinine and serum phosphate levels. The highest levels of plasma SO4 were observed in 15 children undergoing regular dialysis. It is suggested that sulfate retention might be involved in the pathogenesis of uremic acidosis and bone disease.
对38名未接受透析的慢性肾病儿童测定了血浆硫酸盐浓度（SO4），并将其与菊粉清除率及其他肾功能参数进行比较。采用原子吸收分光光度法测定SO4。血浆SO4与肾小球滤过率和有效肾血浆流量呈负相关。血浆SO4与血尿素氮、血清肌酐和血清磷酸盐水平呈正相关。在15名接受定期透析的儿童中观察到最高水平的血浆SO4。提示硫酸盐潴留可能参与了尿毒症酸中毒和骨病的发病机制。
