Ueda K, Ohtaguro K, Washida H, Jinno H, Fushimi N, Masegi T
Prog Clin Biol Res. 1982;107:815-26.
In these studies, double freezing of the prostate was applied to 10 patients with a confirmed histologic diagnosis of stage C and D carcinoma. The clinical courses in the first group (five patients) were favorable. In the second group (two patients), death by cachexia occurred due to the cancer. In the third group (three patients), death 4 weeks after the second cryosurgery suggests the effects of Cryoshock. In the first and second groups, the results of immunologic examinations after the second freezing did not attain the predicted levels. Comparing the results of the third group with those of the first and second groups, the primary difference was that the percentages of gamma globulins and IgE were higher in the third group preoperatively. These findings suggest that in patients with high gamma globulin percentages and high IgE levels cryosurgery of the prostate is contraindicated.
在这些研究中，对10例经组织学确诊为C期和D期癌的患者进行了前列腺双重冷冻治疗。第一组（5例患者）的临床病程良好。第二组（2例患者）因癌症出现恶病质死亡。第三组（3例患者）在第二次冷冻手术后4周死亡，提示存在冷冻休克效应。在第一组和第二组中，第二次冷冻后免疫检查结果未达到预期水平。将第三组的结果与第一组和第二组的结果进行比较，主要差异在于第三组术前γ球蛋白和IgE的百分比更高。这些发现表明，对于γ球蛋白百分比高和IgE水平高的患者，前列腺冷冻手术是禁忌的。
