Bonney W W, Henstorf J E, Emaus S P, Lubaroff D M, Feldbush T L
Natl Cancer Inst Monogr. 1978 Dec(49):375-81.
In patients with prostate cancer, cryosurgery has been highly effective in eradication of the primary tumor. Certain clinical observations have suggested the presence of an additional systemic anticancer effect, presumably immunologic in nature, but proof is lacking. To study this problem further, we developed two animal tumor models. Instead of using the classical subcutaneous site, we transplanted the 11095A and R-3327 prostate tumors into rat prostate, the 4909 bladder tumor into rat bladder. In these respective orthotopic locations, the 3 tumors displayed favorable growth characteristics with good accessibility for cryosurgery. This model should be considered for studies involving any localized treatment of an established urologic tumor.
在前列腺癌患者中，冷冻手术在根除原发性肿瘤方面非常有效。某些临床观察表明存在一种额外的全身抗癌作用，推测其本质上是免疫性的，但缺乏证据。为了进一步研究这个问题，我们开发了两种动物肿瘤模型。我们没有使用经典的皮下部位，而是将11095A和R - 3327前列腺肿瘤移植到大鼠前列腺中，将4909膀胱肿瘤移植到大鼠膀胱中。在这些各自的原位位置，这3种肿瘤表现出良好的生长特性，便于进行冷冻手术。对于涉及任何既定泌尿系统肿瘤局部治疗的研究，都应考虑使用该模型。
