Grovum W L, Chapman H W
Regul Pept. 1982 Dec;5(1):35-42. doi: 10.1016/0167-0115(82)90073-8.
The mechanism whereby pentagastrin inhibits the frequency of contractions of the reticulo-rumen in conscious sheep was studied by comparing the effects of a range of doses given by continuous infusion into the jugular vein and the carotid artery. The intracarotid infusions at rates of 1 and 2 micrograms/kg per h were more effective than the jugular infusions (P less than 0.05). This is the first report that pentagastrin administered intravenously acts directly on the brain to alter the motility of a portion of the digestive tract. This agrees with the fact that in sheep and other ruminants, the gastric centres in the medulla dictate the frequency of cyclical motility in the reticulum.
通过比较颈静脉和颈动脉连续输注一系列剂量的五肽胃泌素对清醒绵羊瘤网胃收缩频率的影响，研究了五肽胃泌素抑制瘤网胃收缩频率的机制。以每小时1和2微克/千克的速率进行的颈内动脉输注比颈静脉输注更有效（P小于0.05）。这是首篇关于静脉注射五肽胃泌素直接作用于大脑以改变消化道某一部分运动性的报道。这与绵羊和其他反刍动物中延髓的胃中枢决定瘤胃周期性运动频率这一事实相符。
