McLeay L M, Pass M A
Department of Biological Sciences, University of Waikato, Hamilton, New Zealand.
Comp Biochem Physiol A Physiol. 1996 Sep;115(1):63-71. doi: 10.1016/0300-9629(96)00004-7.
The effect of short infusions into the hepatic portal vein of propionate on reticulo-rumen motility was examined in conscious sheep. Infusions of 10 min duration of propionate at 1-6 mmol.min-1 into the portal vein reduced the frequency and amplitude of reticulum and rumen contractions, especially the amplitude of rumen contractions. Inhibitory effects were not confined to the portal route and were also obtained via the jugular vein, carotid artery, coeliac artery and anterior mesenteric artery. Butyrate was also effective, but acetate much less so and NaCl almost without effect. The inhibitory responses remained after section of nerves to the liver. It appears unlikely the effects reflexly originate from the liver or are derived centrally.
在清醒绵羊中研究了向肝门静脉短时间输注丙酸盐对瘤网胃运动的影响。以1 - 6 mmol·min⁻¹的速度向门静脉输注丙酸盐10分钟，可降低网胃和瘤胃收缩的频率和幅度，尤其是瘤胃收缩的幅度。抑制作用并不局限于门静脉途径，通过颈静脉、颈动脉、腹腔动脉和肠系膜前动脉输注也可产生抑制作用。丁酸盐也有效，但乙酸盐的效果要小得多，而氯化钠几乎没有效果。切断支配肝脏的神经后，抑制反应仍然存在。这些作用似乎不太可能反射性地起源于肝脏或来自中枢。
