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精氨酸预负荷对儿童和青少年静脉注射胰高血糖素后胰岛素反应无影响。

Lack of influence of arginine preloading on the insulin response to I.V. glucagon in children and adolescents.

作者信息

Blum I, Doron M, Laron Z

出版信息

Acta Diabetol Lat. 1978 Jan-Apr;15(1-2):68-71. doi: 10.1007/BF02581008.

DOI:10.1007/BF02581008
PMID:716771
Abstract

Nine normal children (6 males and 3 females) aged from 7 1/2 to 14 1/2 years underwent a 30-min arginine infusion (0.5 g/kg) followed at 90 min by one bolus i.v. glucagon injection (0.03 mg/kg). On a separate occasion the same children underwent an i.v. glucagon only test. No significant difference was found when the glucose and insulin responses in the two glucagon tests were compared, in contrast to previous findings that preloading with glucose resulted in a significantly increased response of insulin to glucagon.

摘要

9名年龄在7岁半至14岁半的正常儿童(6名男性和3名女性)接受了30分钟的精氨酸输注(0.5克/千克),90分钟后静脉注射一次胰高血糖素(0.03毫克/千克)。在另一个场合,同样的儿童仅接受了静脉注射胰高血糖素测试。与之前葡萄糖预负荷导致胰岛素对胰高血糖素反应显著增加的研究结果相反,比较两次胰高血糖素测试中的葡萄糖和胰岛素反应时未发现显著差异。

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1
Lack of influence of arginine preloading on the insulin response to I.V. glucagon in children and adolescents.精氨酸预负荷对儿童和青少年静脉注射胰高血糖素后胰岛素反应无影响。
Acta Diabetol Lat. 1978 Jan-Apr;15(1-2):68-71. doi: 10.1007/BF02581008.
2
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Metabolism. 1976 Mar;25(3):277-80. doi: 10.1016/0026-0495(76)90085-8.
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本文引用的文献

1
Immunoassay of insulin with insulin-antibody precipitate.用胰岛素 - 抗体沉淀物进行胰岛素免疫测定。
Biochem J. 1963 Jul;88(1):137-46. doi: 10.1042/bj0880137.
2
Characteristics of glucagon action on the hepatic adenylate cyclase system.胰高血糖素对肝脏腺苷酸环化酶系统的作用特性。
Biochem J. 1971 Dec;125(3):58P-59P. doi: 10.1042/bj1250058p.
3
Effect of adrenergic blocking agents on insulin response to glucose infusion in man.肾上腺素能阻滞剂对人体葡萄糖输注胰岛素反应的影响。
Acta Endocrinol (Copenh). 1972 Feb;69(2):335-46. doi: 10.1530/acta.0.0690335.
4
On the action of tolbutamide in normal man. 3. Interaction of tolbutamide with glucagon, aminophylline and arginine in stimulating insulin response.关于甲苯磺丁脲对正常人的作用。3. 甲苯磺丁脲与胰高血糖素、氨茶碱和精氨酸在刺激胰岛素反应中的相互作用。
Acta Endocrinol (Copenh). 1973 Mar;72(3):532-44.
5
The influence of oral glucose loading on the insulin response to i.v. glucagon in children and adolescents.口服葡萄糖负荷对儿童和青少年静脉注射胰高血糖素后胰岛素反应的影响。
Metabolism. 1976 Mar;25(3):277-80. doi: 10.1016/0026-0495(76)90085-8.
6
The effect of hGH deficiency on the insulin response to glucagon after oral glucose loading.生长激素缺乏对口服葡萄糖负荷后胰岛素对胰高血糖素反应的影响。
Diabetologia. 1977 Sep;13(5):447-50. doi: 10.1007/BF01234494.