Riolo U, Pandiani I, Finzi G
Arch Sci Med (Torino). 1982 Oct-Dec;139(4):499-508.
Following a brief of the main requisites of disinfectants, the solutions tested during research are listed: 1) Ethyl alcohol denatured at 70 degrees C. 2) A hydro-alcoholic solution of 0,20% Benzalkonium chloride (F.U.) in association with 0.15% 1-Benzyl-3 [3-Dimethylammoniopropoxy]-1 H-indazol HCl. 3) An acetonic hydro-alcoholic solution of 0.1% Benzoxonium chloride, a water solution of 1% Polyvinylpyrrolidone-iodine (P.V.P.-I), a water solution of 0.5% Chlorhexidine gluconate, and a hydro-alcoholic solution of 0.17% Benzalkonium chloride. The technique used (modified contact test) is illustrated and the results analysed in detail. The best results absolutely were obtained by applying Ethyl alcohol denatured at 70 degrees C and P.V.P.-I in a water solution at a concentration of 1%. Some problem must, however, be borne in mind when using such substances (first, denaturing of proteins, second, action curtailed by temperature). Best results among the Q.A.C. were obtained with the hydro-alcoholic solution of an association of 0.20% Benzalkonium chloride (F.U.) and 0.15% 1-Benzyl-3 [3-Dimethylammoniopropoxy]-1 H-indazol HCl.
在简述消毒剂的主要要求之后，列出了研究过程中测试的溶液：1）70摄氏度变性乙醇。2）0.20%苯扎氯铵（F.U.）与0.15%1-苄基-3-[3-二甲基氨丙氧基]-1H-吲唑盐酸盐的水醇溶液。3）0.1%苯氧氯铵的丙酮水醇溶液、1%聚乙烯吡咯烷酮碘（P.V.P.-I）的水溶液、0.5%葡萄糖酸氯己定的水溶液以及0.17%苯扎氯铵的水醇溶液。阐述了所采用的技术（改良接触试验）并详细分析了结果。绝对最佳结果是通过应用70摄氏度变性乙醇和浓度为1%的聚乙烯吡咯烷酮碘水溶液获得的。然而，使用这些物质时必须牢记一些问题（首先，蛋白质变性；其次，作用受温度限制）。在季铵化合物（Q.A.C.）中，0.20%苯扎氯铵（F.U.）与0.15%1-苄基-3-[3-二甲基氨丙氧基]-1H-吲唑盐酸盐组合的水醇溶液取得了最佳结果。
