Ringsted J, Amtrup F, Asklund C, Baunsgaard P, Christensen H E, Hansen L, Jakobsen C, Jensen K, Moesner J, Rasmussen J, Reintoft I, Rolschau J, Starklint H, Thommesen N, Vrang J
Acta Pathol Microbiol Scand A. 1978 Jul;86(4):273-8. doi: 10.1111/j.1699-0463.1978.tb02043.x.
The reliability of histological diagnosis of squamous epithelial changes was tested by letting 13 pathologists read 1,001 consecutive cervical biopsies twice. Intra-observer and inter-observer agreement, variance, and deviation of diagnosis were determined. The diagnostic ability showed great individual variation and no significant correlation to experience in pathology. The diagnosis of invasive cancer had a high diagnostic specificity, and the diagnostic sensitivity of the diagnosis of no significant epithelial changes was high too. The reliability of the diagnosis of dysplasia and carcinoma in situ proved unsatisfactory.
通过让13位病理学家对1001例连续的宫颈活检标本进行两次阅片，来测试鳞状上皮变化组织学诊断的可靠性。确定了观察者内和观察者间的一致性、诊断的方差和偏差。诊断能力显示出很大的个体差异，且与病理学经验无显著相关性。浸润癌的诊断具有较高的诊断特异性，无显著上皮变化诊断的诊断敏感性也较高。发育异常和原位癌诊断的可靠性被证明是不令人满意的。
