Campbell I T, Walker R F, Riad-Fahmy D, Wilson D W, Griffiths K
Chronobiologia. 1982 Oct-Dec;9(4):389-96.
The variations in concentrations of testosterone and cortisol in saliva samples collected by 4 healthy young men whilst on a scientific expedition from Britain to Spitzbergen are described. The rhythms observed in steroid concentrations in saliva were characterized mathematically by cosinor analysis of the levels of testosterone and cortisol determined in saliva samples collected before, during and after the expedition. Whilst in Spitzbergen, the subjects were maintained initially on the British sleep-wake schedule which was later subjected to an 8-h phase change. Variations in testosterone concentrations in saliva appeared to be largely related to subject activity rather than any photoperiodic effect with rapid resynchronization of the circadian acrophase in response to the phase shift of the sleep-wake schedule. In contrast, variation in salivary cortisol levels appeared to be less related to activity and more dependent on the slower resynchronization of an endogenous rhythm of cortisol secretion.
本文描述了4名健康年轻男性在从英国前往斯匹次卑尔根群岛的科学考察期间采集的唾液样本中睾酮和皮质醇浓度的变化情况。通过对考察前、考察期间和考察后采集的唾液样本中所测定的睾酮和皮质醇水平进行余弦分析，从数学角度对唾液中类固醇浓度所观察到的节律进行了表征。在斯匹次卑尔根群岛期间，受试者最初维持英国的睡眠-清醒时间表，该时间表后来经历了8小时的相位变化。唾液中睾酮浓度的变化似乎在很大程度上与受试者的活动有关，而非任何光周期效应，且随着睡眠-清醒时间表的相位变化，昼夜节律峰相位会迅速重新同步。相比之下，唾液皮质醇水平的变化似乎与活动的关系较小，而更多地依赖于皮质醇分泌内源性节律的较慢重新同步。
