Cheek D B, Wishart J, MacLennan A H, Haslam R, Fitzgerald A
Early Hum Dev. 1982 Dec;7(4):323-30. doi: 10.1016/0378-3782(82)90034-2.
A total of 65 infants, 48 born vaginally and 17 by segment caesarean section, were studied prior to labour for extracellular volume (ECV) (corrected bromide space) and total body water (TBW) (deuterium space) during the first 24 h of postnatal life. The infants were mature and growth retardation excluded. A 'heel stick' blood sample was taken for micro determination of Br and urine for 2H2O concentration. ECV varied from 343 +/- 27 ml/kg at 6 h to 358 +/- 21 ml/kg at 24 h and TBW was 75.5 +/- 3.4% of body weight. Contrary to current opinion, neither TBW nor cell hydration differed in infants born by caesarean section compared with those born vaginally. Such modern methodology to study infant body hydration and the critical assessment of growth and maturity demonstrates that hydration during the first 24 h of life is relatively stable and is not affected by the mode of delivery.
共有65名婴儿参与了研究，其中48名经阴道分娩，17名经分段剖宫产。在出生后24小时内，对这些婴儿出生前的细胞外液量（ECV，校正溴空间）和总体水（TBW，氘空间）进行了研究。这些婴儿均为足月儿，且排除了生长发育迟缓的情况。通过“足跟采血”获取血样以微量测定溴含量，并收集尿液测定重水（2H2O）浓度。细胞外液量在出生后6小时为343±27毫升/千克，到24小时时为358±21毫升/千克，总体水占体重的75.5±3.4%。与目前的观点相反，剖宫产出生的婴儿与经阴道分娩的婴儿相比，总体水和细胞水合状态并无差异。这种研究婴儿身体水合状态的现代方法以及对生长发育和成熟度的严格评估表明，出生后24小时内的水合状态相对稳定，且不受分娩方式的影响。
