van der Vies J
Maturitas. 1982 Dec;4(4):291-9. doi: 10.1016/0378-5122(82)90061-5.
The potency ratio of oestriol compared to oestradiol or to ethinyloestradiol depends on the experimental conditions of the test. If a sufficiently high level of oestriol is maintained in a target tissue, either by infusion or by frequent administration, this steroid is capable of eliciting a full oestrogenic effect. At the target tissue, oestriol is a short-acting rather than a weak-acting oestrogen. This explains why certain oestrogenic effects are not observed after a single administration of oestriol or after far-spaced dosings. The short retention time of oestriol in the target tissues makes the oestrogenic effects dependent on the manner of administration of the compound, in particular on the route of administration and on the frequency of dosing.
雌三醇与雌二醇或炔雌醇的效价比取决于测试的实验条件。如果通过输注或频繁给药在靶组织中维持足够高水平的雌三醇，这种类固醇能够引发完全的雌激素效应。在靶组织中，雌三醇是一种短效而非低效的雌激素。这就解释了为什么单次给予雌三醇或间隔很长时间给药后未观察到某些雌激素效应。雌三醇在靶组织中的保留时间短使得雌激素效应取决于化合物的给药方式，特别是给药途径和给药频率。
