Manzo L, Tartara A, Bo P, Maurelli M, Mazzella G, Savoldi F
Subst Alcohol Actions Misuse. 1982;3(3):153-61.
Rabbits treated with a single IV dose of ethanol, 0.6 g/kg, exhibited rapid EEG synchronization and behavioral changes that were reversed and, in part, prevented by the opiate antagonist, naloxone, 40 micrograms/kg. The continuous intracerebroventricular infusion of acetaldehyde, 10 or 120 micrograms/min. caused biphasic changes with EEG activation and severe bradycardia followed by overt synchrony during the post-infusion period. The results of the present study provide further evidence for the ability of naloxone to counteract some acute effects of ethanol. Moreover, they do not support a role of acetaldehyde itself as mediator of EEG changes associated with mild alcohol intoxication.
用0.6克/千克乙醇单次静脉注射处理的兔子，表现出快速的脑电图同步化和行为变化，这些变化可被40微克/千克的阿片类拮抗剂纳洛酮逆转，且部分可被预防。以每分钟10或120微克的速度持续脑室内注入乙醛，会引起双相变化，先是脑电图激活和严重心动过缓，随后在注入后阶段出现明显的同步化。本研究结果为纳洛酮抵消乙醇某些急性效应的能力提供了进一步证据。此外，它们不支持乙醛本身作为与轻度酒精中毒相关的脑电图变化的介质的作用。
