Beher W T, Dienst S G, Lin G J, Morales A, Stradnieks S
Steroids. 1982 Oct;40(4):413-24. doi: 10.1016/0039-128x(82)90019-8.
The enterohepatic circulation (EHC) of bile acids has been studied in fasting dogs with portacaval shunt maintained in the steady state. In such animals the rate of EHC is proportional to systemic blood bile acid concentration. Bile acid EHC was irregular (20 to 100% variation) when measured at 15 minute or hourly intervals. Studies showed that the variations persisted in cholecystectomized and sphincterectomized animals. The irregularities were enhanced by bethanechol chloride which increases intestinal peristalsis and suppressed by diphenoxylate HCl which slows peristalsis. The variations appear to arise from irregular patterns of intestinal peristalsis. This phenomenon may explain some variations in blood bile acid concentration observed in patients with liver disease.
在维持门静脉分流稳定状态的空腹犬中研究了胆汁酸的肠肝循环（EHC）。在此类动物中，EHC的速率与全身血液胆汁酸浓度成正比。以15分钟或每小时为间隔测量时，胆汁酸EHC不规则（变化20%至100%）。研究表明，胆囊切除和括约肌切除的动物中仍存在这种变化。氯化氨甲酰甲胆碱可增强这种不规则性，它会增加肠道蠕动，而盐酸地芬诺酯可抑制这种不规则性，它会减缓蠕动。这些变化似乎源于肠道蠕动的不规则模式。这种现象可能解释了在肝病患者中观察到的血液胆汁酸浓度的一些变化。
