胆囊切除术后胆汁酸的肠肝循环。
Enterohepatic circulation of bile acids after cholecystectomy.
作者信息
Roda E, Aldini R, Mazzella G, Roda A, Sama C, Festi D, Barbara L
出版信息
Gut. 1978 Jul;19(7):640-9. doi: 10.1136/gut.19.7.640.
Abstract
Bile acid metabolism was investigated in 10 patients after cholecystectomy, 10 gallstone patients, and 10 control subjects. Diurnal variations of serum levels of cholic and chenodeoxycholic acid conjugates were not abolished by cholecystectomy. Cholic acid pool size was significantly reduced in cholecystectomised patients and the fractional turnover rate and the rate of intestinal degradation of bile acid showed a significant increase. In cholecystectomised patients fasting bile was supersaturated in cholesterol, though less than in gallstone patients, but, in both, feeding resulted in improvement of cholesterol solubility in bile. These data suggest that after cholecystectomy the small intestine alone acts as a pump in regulating the dynamics of the enterohepatic circulation of bile acids and that the improvement of cholesterol solubility in bile is due to a more rapid circulation of the bile acid pool in fasting cholecystectomised patients.
摘要
对10例胆囊切除术后患者、10例胆结石患者和10例对照受试者的胆汁酸代谢进行了研究。胆囊切除术后，胆酸和鹅去氧胆酸结合物的血清水平昼夜变化并未消除。胆囊切除患者的胆酸池大小显著减小，胆汁酸的分数周转率和肠道降解率显著增加。在胆囊切除患者中，空腹胆汁中的胆固醇呈过饱和状态，尽管低于胆结石患者，但在两者中，进食均导致胆汁中胆固醇溶解度的改善。这些数据表明，胆囊切除术后，仅小肠就起到了调节胆汁酸肠肝循环动力学的泵的作用，并且空腹胆囊切除患者胆汁中胆固醇溶解度的改善是由于胆汁酸池循环更快。
相似文献
1
Enterohepatic circulation of bile acids after cholecystectomy.胆囊切除术后胆汁酸的肠肝循环。
Gut. 1978 Jul;19(7):640-9. doi: 10.1136/gut.19.7.640.
2
Diurnal serum levels of primary conjugated bile acids. Assessment by specific radioimmunoassays for conjugates of cholic and chenodeoxycholic acid.初级结合胆汁酸的日间血清水平。通过针对胆酸和鹅去氧胆酸结合物的特异性放射免疫测定法进行评估。
Gut. 1978 Nov;19(11):1006-14. doi: 10.1136/gut.19.11.1006.
3
Portal venous bile acids in cholesterol gallstone disease: effect of treatment with chenodeoxycholic and cholic acids.胆固醇结石病中门静脉胆汁酸：鹅去氧胆酸和胆酸治疗的效果
Hepatology. 1985 Jul-Aug;5(4):661-5. doi: 10.1002/hep.1840050423.
4
Effect of decreased gallbladder stimulation on enterohepatic cycling and kinetics of bile acids.胆囊刺激减少对胆汁酸肠肝循环及动力学的影响。
Gastroenterology. 1975 Jun;68(6):1574-81.
5
Composition of biliary lipids and kinetics of bile acids after cholecystectomy in man.人类胆囊切除术后胆汁脂质的组成及胆汁酸的动力学
Am J Dig Dis. 1976 Sep;21(9):776-81. doi: 10.1007/BF01073029.
6
Effect of primary bile acid ingestion on bile acid metabolism and biliary lipid secretion in gallstone patients.原发性胆汁酸摄入对胆结石患者胆汁酸代谢及胆汁脂质分泌的影响。
Gastroenterology. 1975 Dec;69(6):1301-14.
7
Bile acids, cholesterol, gallstone calcification, and the enterohepatic circulation of bilirubin.胆汁酸、胆固醇、胆结石钙化以及胆红素的肠肝循环。
Gastroenterology. 1999 May;116(5):1276-7. doi: 10.1016/s0016-5085(99)70042-9.
8
The enterohepatic circulation of conjugated bile acids in healthy man: quantitative description and functions.
Expos Annu Biochim Med. 1977;33:69-86.
9
Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum.人体肝脏对胆汁酸的摄取。门静脉血和体循环血清中空腹及餐后各胆汁酸的浓度。
J Clin Invest. 1982 Oct;70(4):724-31. doi: 10.1172/jci110668.
10
Enterohepatic circulation rates of cholic acid and chenodeoxycholic acid in man.人体内胆酸和鹅去氧胆酸的肠肝循环率。
Gut. 1979 Dec;20(12):1078-82. doi: 10.1136/gut.20.12.1078.
引用本文的文献
1
Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis.胆囊切除相关的肠道微生物群失调会加剧结直肠癌的发生。
Nat Commun. 2025 Aug 16;16(1):7638. doi: 10.1038/s41467-025-62956-8.
2
Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study.胆囊切除术与代谢健康变化和心血管疾病发病的关联：一项回顾性队列研究。
Sci Rep. 2024 Feb 8;14(1):3195. doi: 10.1038/s41598-024-53161-6.
3
Does postcholecystectomy increase the risk of colorectal cancer?胆囊切除术后会增加患结直肠癌的风险吗？
Front Microbiol. 2023 Jun 22;14:1194419. doi: 10.3389/fmicb.2023.1194419. eCollection 2023.
4
Complex impacts of gallstone disease on metabolic syndrome and nonalcoholic fatty liver disease.胆囊疾病对代谢综合征和非酒精性脂肪性肝病的复杂影响。
Front Endocrinol (Lausanne). 2022 Nov 23;13:1032557. doi: 10.3389/fendo.2022.1032557. eCollection 2022.
5
Cholecystectomy-induced secondary bile acids accumulation ameliorates colitis through inhibiting monocyte/macrophage recruitment.胆囊切除术引起的次级胆汁酸积累通过抑制单核细胞/巨噬细胞募集来改善结肠炎。
Gut Microbes. 2022 Jan-Dec;14(1):2107387. doi: 10.1080/19490976.2022.2107387.
6
Correlation between cholecystectomy and development of non-alcoholic liver disease in the mouse model.小鼠模型中胆囊切除术与非酒精性肝病发生之间的相关性。
Ann Transl Med. 2022 Aug;10(15):814. doi: 10.21037/atm-21-5414.
7
Cholecystectomy and subsequent risk of Parkinson's disease: a nationwide retrospective cohort study.胆囊切除术与帕金森病的后续风险：一项全国性回顾性队列研究。
NPJ Parkinsons Dis. 2021 Nov 16;7(1):100. doi: 10.1038/s41531-021-00245-z.
8
Cholecystectomy as a risk factor for metabolic dysfunction-associated fatty liver disease: unveiling the metabolic and chronobiologic clues behind the bile acid enterohepatic circulation.胆囊切除术作为代谢功能障碍相关脂肪性肝病的危险因素：揭示胆汁酸肠肝循环背后的代谢和生物钟线索
J Physiol Biochem. 2021 Nov;77(4):497-510. doi: 10.1007/s13105-020-00782-w. Epub 2021 Jul 24.
9
Bacterial Alterations in Post-Cholecystectomy Patients Are Associated With Colorectal Cancer.胆囊切除术后患者的细菌改变与结直肠癌有关。
Front Oncol. 2020 Aug 12;10:1418. doi: 10.3389/fonc.2020.01418. eCollection 2020.
10
A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings.在健康和病理条件下人类胆汁酸分布和代谢的基于生理学的模型。
Cell Mol Gastroenterol Hepatol. 2020;10(1):149-170. doi: 10.1016/j.jcmgh.2020.02.005. Epub 2020 Feb 26.
本文引用的文献
1
Enzymic analysis of steroid hormones.类固醇激素的酶分析
Methods Biochem Anal. 1960;8:119-43. doi: 10.1002/9780470110249.ch3.
2
The turnover of cholic acid in man: bile acids and steroids.人体内胆酸的周转：胆汁酸与类固醇
Acta Physiol Scand. 1957 Sep 17;40(1):1-9. doi: 10.1111/j.1748-1716.1957.tb01473.x.
3
The physicochemical basis of cholesterol gallstone formation in man.人类胆固醇胆结石形成的物理化学基础。
J Clin Invest. 1968 May;47(5):1043-52. doi: 10.1172/JCI105794.
4
Influence of cholestyramine, bile salt, and cholesterol feeding on the lipid composition of hepatic bile in man.
Scand J Gastroenterol. 1970;5(7):603-8.
5
Source of abnormal bile in patients with cholesterol gallstones.胆固醇结石患者异常胆汁的来源。
N Engl J Med. 1970 Jul 9;283(2):53-7. doi: 10.1056/NEJM197007092830201.
6
Importance of bile acids for phospholipid secretion into human hepatic bile.胆汁酸对磷脂分泌入人肝胆汁的重要性。
Gastroenterology. 1969 Nov;57(5):525-32.
7
Relationship of bile acid pool size to biliary lipid excretion and the formation of lithogenic bile in man.人体胆汁酸池大小与胆汁脂质排泄及致石性胆汁形成的关系。
Gastroenterology. 1971 Nov;61(5):716-22.
8
The solubility of cholesterol in aqueous solutions of bile salts and lecithin.胆固醇在胆盐和卵磷脂水溶液中的溶解度。
Z Ernahrungswiss. 1971 Apr;10(3):223-33. doi: 10.1007/BF02020933.
9
Alterations in hepatic bile composition after cholecystectomy.胆囊切除术后肝脏胆汁成分的改变。
Gastroenterology. 1972 Sep;63(3):466-71.
10
Diminished bile acid pool size in patients with gallstones.胆结石患者胆汁酸池大小减小。
Gastroenterology. 1970 Aug;59(2):165-73.
Zotero 插件