Roda E, Aldini R, Mazzella G, Roda A, Sama C, Festi D, Barbara L
Gut. 1978 Jul;19(7):640-9. doi: 10.1136/gut.19.7.640.
Bile acid metabolism was investigated in 10 patients after cholecystectomy, 10 gallstone patients, and 10 control subjects. Diurnal variations of serum levels of cholic and chenodeoxycholic acid conjugates were not abolished by cholecystectomy. Cholic acid pool size was significantly reduced in cholecystectomised patients and the fractional turnover rate and the rate of intestinal degradation of bile acid showed a significant increase. In cholecystectomised patients fasting bile was supersaturated in cholesterol, though less than in gallstone patients, but, in both, feeding resulted in improvement of cholesterol solubility in bile. These data suggest that after cholecystectomy the small intestine alone acts as a pump in regulating the dynamics of the enterohepatic circulation of bile acids and that the improvement of cholesterol solubility in bile is due to a more rapid circulation of the bile acid pool in fasting cholecystectomised patients.
对10例胆囊切除术后患者、10例胆结石患者和10例对照受试者的胆汁酸代谢进行了研究。胆囊切除术后，胆酸和鹅去氧胆酸结合物的血清水平昼夜变化并未消除。胆囊切除患者的胆酸池大小显著减小，胆汁酸的分数周转率和肠道降解率显著增加。在胆囊切除患者中，空腹胆汁中的胆固醇呈过饱和状态，尽管低于胆结石患者，但在两者中，进食均导致胆汁中胆固醇溶解度的改善。这些数据表明，胆囊切除术后，仅小肠就起到了调节胆汁酸肠肝循环动力学的泵的作用，并且空腹胆囊切除患者胆汁中胆固醇溶解度的改善是由于胆汁酸池循环更快。
