Baier R E, Meyer A E, Akers C K, Natiella J R, Meenaghan M, Carter J M
Biomaterials. 1982 Oct;3(4):241-5. doi: 10.1016/0142-9612(82)90027-8.
Prior to implantation trials in animals, the effect of steam sterilization on the surface properties of metallic and coated biomaterials was studied. Pure germanium plates and cast surgical Vitallium discs and subperiosteal implants were treated to present three standard types of biomaterials surfaces prior to steam sterilization, ranging from scrupulously clean, high-energy metals to uniformly low-energy organic layers. Both before and after sterilization, the sample surfaces were characterized by a variety of nondestructive physiochemical techniques. The results indicate that steam sterilization is likely to compromise the properties of otherwise carefully prepared biomedical implants by depositing hydrophobic organic and hygroscopic salt contaminants over the implant surfaces.
在进行动物植入试验之前，研究了蒸汽灭菌对金属及涂层生物材料表面性能的影响。在蒸汽灭菌之前，对纯锗板、铸造外科用维塔利姆合金圆盘及骨膜下植入物进行处理，以呈现三种标准类型的生物材料表面，从极其洁净的高能金属到均匀的低能有机层。在灭菌前后，均采用多种无损物理化学技术对样品表面进行表征。结果表明，蒸汽灭菌可能会在植入物表面沉积疏水性有机污染物和吸湿性盐污染物，从而损害原本精心制备的生物医学植入物的性能。
