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[完整皮层及感觉运动皮层分离条带对甲状腺素全身给药的神经元反应]

[Neuronal responses of the intact cortex and isolated strips of the sensorimotor cortex to systemic administration of thyroxine].

作者信息

Amiragova M G, Kuksgaus N E

出版信息

Biull Eksp Biol Med. 1982 Sep;94(9):10-2.

PMID:7171806
Abstract

The pattern of neuronal responses to alterations in hormonal homeostasis was specified. A study was made of neuronal responses of intact and neuronally isolated strips of the sensorimotor cortex (ISC) to intravenous injection of thyroxine. The neuronal response of the ISC was found to differ substantially from the response of intact cortical neurons. Less percentage of the responding neurons was registered in the ISC. The responses were considerably shortened, while the neurons discharged at a lower frequency. The differences indicate that, as compared to subcortical structures, the cortical neurons are less susceptible to blood hormones. It is emphasized that subcortical structures, particularly the hypothalamus are of major importance for transmission of hormonal influences to the brain cortex.

摘要

确定了神经元对激素稳态变化的反应模式。对完整的和神经元分离的感觉运动皮层(ISC)条带对静脉注射甲状腺素的神经元反应进行了研究。发现ISC的神经元反应与完整皮层神经元的反应有很大不同。在ISC中记录到的反应神经元百分比更低。反应明显缩短,而神经元放电频率更低。这些差异表明,与皮层下结构相比,皮层神经元对血液中的激素不太敏感。需要强调的是,皮层下结构,尤其是下丘脑,对于将激素影响传递到大脑皮层至关重要。

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