人类伤寒热期间免疫反应的发展。
Development of immune response during typhoid fever in man.
作者信息
Sarma V N, Malaviya A N, Kumar R, Ghai O P, Bakhtary M M
出版信息
Clin Exp Immunol. 1977 Apr;28(1):35-9.
The development of both humoral and cell-mediated immune responses (CMIR) to antigens prepared from Salmonella typhi was investigated in patients suffering from typhoid fever. The antibodies were determined by the standard Widal test while the leucocyte migration test was used for CMIR. These immunological parameters were correlated with the duration of illness, the duration of chloramphenicol therapy and the severity of the illness. It was found that CMIR appeared after the first week of illness in uncomplicated cases of typhoid fever, where as it remained negative in the patients who had complications. The antibody titres were similar in the two groups. On further follow up of complicated cases, the clinical recovery coincided with the development of CMIR. It may be concluded that for recovery in typhoid fever CMIR is more important than antibodies.
对伤寒热患者针对伤寒沙门氏菌制备的抗原的体液免疫和细胞介导免疫反应（CMIR）的发展情况进行了研究。通过标准维达试验测定抗体，而白细胞迁移试验用于检测CMIR。这些免疫学参数与病程、氯霉素治疗时间和疾病严重程度相关。结果发现，在无并发症的伤寒热病例中，CMIR在发病第一周后出现，而在有并发症的患者中则呈阴性。两组的抗体滴度相似。对有并发症的病例进一步随访发现，临床康复与CMIR的发展同时发生。可以得出结论，对于伤寒热的康复，CMIR比抗体更重要。
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