Gootman N, Buckley B J, Gootman P M, Nagelberg J S
Dev Pharmacol Ther. 1982;4(3-4):139-50. doi: 10.1159/000457403.
The cardiovascular effects of single intravenous injections of dopamine (DPA; 2, 5, 10 and 25 micrograms/kg) were evaluated in swine, less than or equal to 1 day to 2 months of age, anesthetized with halothane in 50% N2O-O2. Mean aortic pressure increased following all doses of DPA in swine less than or equal to 1 month of age. Renal vasoconstriction was obtained with 5-25 micrograms/kg in the younger animals and with 25 micrograms/kg in the oldest. After 2 micrograms/kg, renal vasodilation occurred in 2-month-old swine. Femoral and carotid vasoconstriction was elicited in day-old swine after 5-25 micrograms/kg DPA, but carotid vasodilation occurred in the oldest swine. Responses to 25 micrograms/kg DPA after combined alpha and beta adrenergic receptor blockade were generally vasodilator. Thus, dopaminergic receptors were unmasked and a postnatal maturation of these receptors was revealed.
对年龄小于或等于1天至2个月的猪，用氟烷在50% N₂O - O₂中麻醉，评估单次静脉注射多巴胺（DPA；2、5、10和25微克/千克）对心血管的影响。在年龄小于或等于1个月的猪中，所有剂量的DPA注射后平均主动脉压均升高。在较年幼的动物中，5 - 25微克/千克剂量可引起肾血管收缩，在最年长的动物中，25微克/千克剂量可引起肾血管收缩。2微克/千克剂量后，2月龄猪出现肾血管舒张。5 - 25微克/千克DPA注射后，日龄猪出现股动脉和颈动脉血管收缩，但最年长的猪出现颈动脉血管舒张。联合α和β肾上腺素能受体阻断后对25微克/千克DPA的反应通常为血管舒张。因此，多巴胺能受体被暴露，且显示出这些受体的出生后成熟过程。
