Itoh Z, Takeuchi S, Aizawa I, Mori K, Taminato T, Seino Y, Imura H, Yanaihara N
Am J Dig Dis. 1978 Oct;23(10):929-35. doi: 10.1007/BF01072469.
Simultaneous measurement of plasma motilin concentration and gastrointestinal contractile activity was make in 12 healthy dogs. Plasma motilin concentration was measured by radioimmunoassay and gastrointestinal contractile activity was monitored by means of chronically implanted force transducers. During the interdigestive state, it was found that the plasma motilin concentration increased in complete accordance with the cyclical interdigestive contractions of the stomach. Furthermore, plasma motilin concentration was lowered by the ingestion of food, and it reamined low as long as the gastric motor activity was in the digestive pattern. Since, as reported previously the interdigestive contractions can be induced by tthe exogenous administration of motilin, we concluded that (1) motilin is released at constant intervals during the interdigestive state, and this release is suppressed by the ingestion of food; (2) motilin induces the interdigestive contractions of the stomach and duodenum; and (3) motilin is an interdigestive hormone and is the only known polypeptide hormone of the gut whose release is not induced by a meal.
对12只健康犬同时进行血浆胃动素浓度和胃肠收缩活动的测定。采用放射免疫分析法测定血浆胃动素浓度，通过长期植入的力传感器监测胃肠收缩活动。在消化间期，发现血浆胃动素浓度的升高与胃的周期性消化间期收缩完全一致。此外，进食可使血浆胃动素浓度降低，只要胃运动活动处于消化模式，该浓度就维持在较低水平。由于如先前报道，外源性给予胃动素可诱发消化间期收缩，我们得出以下结论：（1）在消化间期，胃动素以固定间隔释放，进食可抑制这种释放；（2）胃动素可诱发胃和十二指肠的消化间期收缩；（3）胃动素是一种消化间期激素，是已知唯一一种其释放不是由进食诱导的肠道多肽激素。
