Marti J, Fournie P, Lafont J
Differentiation. 1982;22(3):201-4. doi: 10.1111/j.1432-0436.1982.tb01251.x.
2'5'-Oligoadenylates are potent protein synthesis inhibitors: they are synthesized by a polymerase which was first described in interferon-treated cells. This system may also be involved in a normal process of cell proliferation and differentiation, in the absence of any viral infection. The small intestine enterocyte has been investigated as a model to test this hypothesis. The presence of 2'5'-oligoadenylate polymerase activity is demonstrated in the intestinal mucosa of normal adult rats. The distribution of this enzyme, and of the enzymes degrading 2'5' oligoadenylates have been investigated on enterocyte pools selectively extracted, under mild conditions, from the different parts of the rat small intestine. Similar results were obtained with enterocytes extracted from the mucosa of germ-free animals.
2',5'-寡腺苷酸是强效的蛋白质合成抑制剂：它们由一种聚合酶合成，这种聚合酶最初是在经干扰素处理的细胞中被描述的。在没有任何病毒感染的情况下，该系统可能也参与细胞增殖和分化的正常过程。小肠肠上皮细胞已被作为一个模型来检验这一假设。在正常成年大鼠的肠黏膜中证实存在2',5'-寡腺苷酸聚合酶活性。在温和条件下从大鼠小肠不同部位选择性提取的肠上皮细胞库中，对这种酶以及降解2',5'-寡腺苷酸的酶的分布进行了研究。从无菌动物黏膜中提取的肠上皮细胞也得到了类似结果。
