Dubois A, Price S F, Castell D O
Am J Dig Dis. 1978 Nov;23(11):993-7. doi: 10.1007/BF01263098.
The saline load test is a popular method to demonstrate gastric retention. This technique, however, does not permit evaluation of volumes contributed by gastric secretion. We have studied 11 normal subjects and 7 patients with pyloric outlet obstruction using a dyedilution technique. We measured simultaneously rates of water secretion, fractional emptying rates, total intragastric volumes, and the fractions of gastric volume contributed by gastric secretion both during fasting and following a 250-ml water load. Total intragastric volume was significantly increased in patients with outlet obstruction compared to normal subjects both during fasting and following the water load (P less than 0.01). This increase resulted from significantly increased water secretion (P less than 0.01) combined with significantly decreased gastric emptying (P less than 0.01). Thus, gastric retention produced in patients with outlet obstruction by delayed emptying appears to be magnified by gastric hypersecretion of water. These data in no way invalidate the use of the saline load test in the diagnosis of gastric retention states, but help define the role of gastric secretion in the residual volumes measured following the load.
盐水负荷试验是一种用于证明胃潴留的常用方法。然而，该技术无法评估胃分泌所产生的容量。我们使用染料稀释技术对11名正常受试者和7名幽门出口梗阻患者进行了研究。我们同时测量了禁食期间以及给予250毫升水负荷后水的分泌速率、排空分数、胃内总体积以及胃分泌对胃体积的贡献比例。与正常受试者相比，出口梗阻患者在禁食期间和给予水负荷后胃内总体积均显著增加（P<0.01）。这种增加是由于水分泌显著增加（P<0.01）与胃排空显著减少（P<0.01）共同导致的。因此，出口梗阻患者因排空延迟产生的胃潴留似乎因胃水分泌过多而加剧。这些数据绝不会使盐水负荷试验在胃潴留状态诊断中的应用无效，而是有助于明确胃分泌在负荷后测量的残余体积中的作用。
