[Distribution of non-steroidal anti-inflammatory agents in human tissues].

Non-steroidal antirheumatic drugs (NSAIDs) have become essential in the treatment of chronic joint disease. The dosage has to be established individually for each patient because the resorption is independent from body size and body weight. After repeated administration NSAIDs are selectively concentrated in the inflamed tissue, which therefore has to be considered an independent compartment for the distribution of the drug. The concentration in this compartment is related to the basic disease and its degree of activity. With increasing activity of the disease the concentrations of NASIDs increase in the involved tissues.