Köhler G
Fortschr Med. 1982 Oct 7;100(37):1723-7.
Non-steroidal antirheumatic drugs (NSAIDs) have become essential in the treatment of chronic joint disease. The dosage has to be established individually for each patient because the resorption is independent from body size and body weight. After repeated administration NSAIDs are selectively concentrated in the inflamed tissue, which therefore has to be considered an independent compartment for the distribution of the drug. The concentration in this compartment is related to the basic disease and its degree of activity. With increasing activity of the disease the concentrations of NASIDs increase in the involved tissues.
非甾体类抗风湿药物（NSAIDs）已成为慢性关节疾病治疗中的重要药物。由于药物吸收与体型和体重无关，因此必须为每位患者单独确定剂量。反复给药后，NSAIDs会选择性地在炎症组织中富集，因此必须将炎症组织视为药物分布的一个独立隔室。该隔室中的药物浓度与基础疾病及其活动程度有关。随着疾病活动度增加，受累组织中NSAIDs的浓度也会升高。
