Köhler G, Primbs P, Morand J, Rübelt C
Clin Rheumatol. 1985 Dec;4(4):399-404. doi: 10.1007/BF02031891.
Fourteen patients with acute lumbar pain and cervico-brachial radicular pain were treated with a single oral dose of 100 mg ketoprofen. The analgesic effect of the substance was investigated, using an analog pain scale, in correlation with drug plasma levels. Blood samples were taken at zero, one-half, one, two, three, four, five, six, eight, and ten hours after oral administration of ketoprofen. On an average, pain was at its lowest two hours after the plasma level of ketoprofen was at its highest. Within the ten hour observation period, the maximum reduction in pain increased as the maximum plasma level rose. Five patients with a maximum plasma level greater than 9 microliter/ml experienced pain reduction of at least 50%.
14例急性腰痛和颈臂放射性疼痛患者口服100毫克酮洛芬单次剂量进行治疗。使用模拟疼痛量表，研究该药物的镇痛效果，并与药物血浆水平进行相关性分析。在口服酮洛芬后0小时、半小时、1小时、2小时、3小时、4小时、5小时、6小时、8小时和10小时采集血样。平均而言，在酮洛芬血浆水平达到最高值后两小时疼痛程度最低。在10小时的观察期内，随着血浆最高水平的升高，疼痛最大程度的减轻也随之增加。5例血浆最高水平大于9微升/毫升的患者疼痛减轻至少50%。
