Schneider P, Tosch W, Maurer M, Zak O
J Antibiot (Tokyo). 1982 Jul;35(7):843-9. doi: 10.7164/antibiotics.35.843.
A pharmacokinetic model has been developed, by means of which all possible time courses of the concentrations of antibiotics in the plasma of treated individuals can be exactly simulated in vitro without diluting the test organism and affecting the growth curves. Equieffective concentrations in the system corresponded to the plasma concentrations in man produced by cefroxadine in a single oral dose of 250 mg and cephalexin and cephradine in a single oral dose of 500 mg.
已经建立了一种药代动力学模型，通过该模型，可以在不稀释受试生物体且不影响生长曲线的情况下，在体外精确模拟接受治疗个体血浆中抗生素浓度的所有可能时间进程。该系统中的等效浓度相当于头孢沙定单次口服250 mg、头孢氨苄和头孢拉定单次口服500 mg在人体中产生的血浆浓度。
