头孢拉定在人体静脉注射和血管外给药后血清水平的药代动力学解释。
Pharmacokinetic interpretation of cephradine levels in serum after intravenous and extravascular administration in humans.
作者信息
Rattie E S, Bernardo P D, Ravin J J
出版信息
Antimicrob Agents Chemother. 1976 Aug;10(2):283-7. doi: 10.1128/AAC.10.2.283.
Abstract
Pharmacokinetic parameters were calculated from intravenous data based upon a two-compartment open model. These parameters were subsequently used to determine the absorption rates and bioavailability of cephradine administered intramuscularly and orally. The results indicate that cephradine obeys dose-independent kinetics and that biological availability is complete from all dosage forms.
摘要
药代动力学参数是基于二室开放模型从静脉注射数据计算得出的。随后，这些参数被用于确定头孢拉定肌肉注射和口服给药后的吸收速率和生物利用度。结果表明，头孢拉定符合剂量非依赖性动力学，并且所有剂型的生物利用度均完全。
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