Genetic and immunohematologic factors in autism.

The present study is being conducted to explore the hypothesis that genetic and/or congenital factors are etiologically significant in certain persons with the syndrome of autism. To initiate the project, the UCLA Registry for Genetic Studies in Autism was established in 1980. To date 254 families have enrolled. Extensive clinical material and past medical data are being gathered from each family. Information presented in this preliminary report is based solely upon parental reports and prior medical and school evaluations, as the diagnoses have not yet been verified by the authors. Clinical data and family pedigrees will be analyzed by computer-based methods. Blood studies including chromosomes, gene markers, T-cell and B-cell functions, and antibody levels are being conducted on families meeting specific research criteria.