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Complementary recessive 25-hydroxycholesterol-resistant somatic cell mutants--assay of 25-hydroxycholesterol binding activity.

作者信息

Sinensky M, Logel J, Torget R

出版信息

J Cell Physiol. 1982 Nov;113(2):314-9. doi: 10.1002/jcp.1041130220.

DOI:10.1002/jcp.1041130220
PMID:7174733
Abstract

Complementation analysis of recessive 25-hydroxycholesterol-resistant mutants of the CHO-Kl cell shows the existence of at least two complementation groups, one of which is missing a binding activity for 25-hydroxycholesterol. Both complementation groups are shown to be refractory to inhibition of cellular HMG-CoA reductase activity and in the inhibition of biosynthesis of this enzyme by 25-hydroxycholesterol.

摘要

相似文献

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Complementary recessive 25-hydroxycholesterol-resistant somatic cell mutants--assay of 25-hydroxycholesterol binding activity.
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