McGill M, Hopkins D A, Armour J A
J Auton Nerv Syst. 1982 Sep;6(2):157-71. doi: 10.1016/0165-1838(82)90048-0.
Anatomical studies have indicated that the middle cervical ganglion is the primary locus of sympathetic postganglionic neurons which have axons projecting in canine cardiac nerves. Small regions of thoracic sympathetic ganglia were stimulated electrically with bipolar electrodes and the generated compound action potentials were recorded from ipsilateral cardiac nerves. Several procedures were used to distinguish the effects of stimulating preganglionic axons, ganglionic sites and postganglionic axons. Following hexamethonium it was found that only low frequency stimulation (e.g. 1 Hz) of ganglionic sites resulted in the generation of compound action potentials in cardiac nerves. These ganglionic sites were located throughout the middle cervical ganglion, but only in the cranial medial pole of the stellate ganglion. Stimulation of a single locus in a stellate or middle cervical ganglion generated compound action potentials in all major ipsilateral sympathetic cardiac nerves. A ganglion was also identified at the junction of the thoracic vagus and the cranial vagal nerve which may be as important as the right stellate ganglion in cardiac regulation. These results demonstrate that there are discrete loci in thoracic ganglia which contain neurons projecting in several ipsilateral cardiac nerves. Low frequency stimulation of these loci was found to be optimal for generation of compound action potentials.
解剖学研究表明，颈中神经节是交感神经节后神经元的主要位点，这些神经元的轴突投射到犬的心神经中。用双极电极对胸交感神经节的小区域进行电刺激，并从同侧心神经记录产生的复合动作电位。采用了几种方法来区分刺激节前轴突、神经节部位和节后轴突的效果。注射六甲铵后发现，只有对神经节部位进行低频刺激（如1赫兹）才能在心神经中产生复合动作电位。这些神经节部位遍布颈中神经节，但仅位于星状神经节的颅内侧极。刺激星状神经节或颈中神经节中的单个位点，可在所有主要的同侧交感心神经中产生复合动作电位。在胸迷走神经和颅迷走神经的交界处还发现了一个神经节，它在心脏调节中可能与右星状神经节同样重要。这些结果表明，胸神经节中存在离散的位点，其中包含投射到几条同侧心神经中的神经元。发现对这些位点进行低频刺激最有利于产生复合动作电位。
