免疫球蛋白重链同种异型与多发性硬化症
Gm allotypes and multiple sclerosis.
作者信息
Propert D N, Bernard C C, Simons M J
出版信息
J Immunogenet. 1982 Oct;9(5):359-61. doi: 10.1111/j.1744-313x.1982.tb00994.x.
Abstract
Immunoglobulin allotypes (Gm) were analysed in 40 multiple sclerosis (MS) patients and the distribution of phenotypes compared to that in 1220 healthy controls. The frequencies of GM(1) and Gm(1, 2) are significantly increased inthe patients suggesting that the presence of the Gm3;5, 13, 14 haplotype confers a resistance to the development of MS.
摘要
对40例多发性硬化症（MS）患者的免疫球蛋白同种异型（Gm）进行了分析，并将其表型分布与1220名健康对照者的表型分布进行了比较。患者中GM(1)和Gm(1, 2)的频率显著增加，这表明Gm3;5, 13, 14单倍型的存在赋予了对MS发病的抗性。
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