免疫球蛋白同种异型与多发性硬化易感性。法国上比利牛斯省的一项流行病学与遗传学研究。

Immunoglobulin allotypes and susceptibility to multiple sclerosis. An epidemiological and genetic study in the Hautes-Pyrénées county of France.

作者信息

Blanc M, Clanet M, Berr C, Dugoujon J M, Ruydavet B, Ducos S J, Rascol A, Alpérovitch A

出版信息

J Neurol Sci. 1986 Aug;75(1):1-5. doi: 10.1016/0022-510x(86)90045-6.

Abstract

Serum samples collected from 69 patients with multiple sclerosis (MS) living in the Hautes-Pyrénées county were tested for immunoglobulin Gm gamma 1, gamma 2, and gamma 3, heavy chain allotypes (Gm system), and immunoglobulin light chain Kappa (Km system). A control group was made up of normal individuals living in the same county. We found a significant excess of individuals with Gm3; +/- 23;5/Gm3; +/- 23;5 amongst the MS patients as compared with controls (relative risk = 2.4). A slight increase of the Km (1) frequency was found in MS patients compared with controls, 21.7% vs 11.8%, but this difference was not significant.

摘要

对居住在比利牛斯-大西洋省的69例多发性硬化症（MS）患者采集的血清样本进行免疫球蛋白Gmγ1、γ2和γ3重链同种异型（Gm系统）以及免疫球蛋白轻链κ（Km系统）检测。对照组由居住在同一省份的正常个体组成。我们发现，与对照组相比，MS患者中Gm3；+/- 23；5/Gm3；+/- 23；5个体显著过多（相对风险=2.4）。与对照组相比，MS患者中Km（1）频率略有增加，分别为21.7%和11.8%，但这种差异不显著。