Haile R W, Goldstein A, Field L, Marazita M L
Genet Epidemiol. 1985;2(1):29-34. doi: 10.1002/gepi.1370020104.
We conducted linkage analyses of immunoglobulin G heavy chain marker (Gm) phenotypes and multiple sclerosis (MS) in 30 families, each having at least two first-degree relatives with definite/probable MS. These families yielded positive evidence for linkage to human leukocyte antigen (HLA) loci in previous analyses. In the present analysis, however, the results for Gm were negative. Most lod scores were negative, particularly at the smaller recombination values (theta). We explored the possibility of heterogeneity by subgrouping our data on the basis of specific HLA types (A3, B7) and Gm types (Gm1, Gm1,2) within the pedigrees. The results were again negative with no substantial differences in estimates of theta between subgroups.
我们对30个家庭中的免疫球蛋白G重链标记（Gm）表型与多发性硬化症（MS）进行了连锁分析，每个家庭至少有两个患有明确/可能MS的一级亲属。在之前的分析中，这些家庭产生了与人类白细胞抗原（HLA）位点连锁的阳性证据。然而，在本分析中，Gm的结果为阴性。大多数对数优势比分数为阴性，尤其是在较小的重组值（θ）时。我们通过根据家系内特定的HLA类型（A3、B7）和Gm类型（Gm1、Gm1,2）对数据进行亚组分析，探讨了异质性的可能性。结果再次为阴性，亚组之间θ估计值无实质性差异。
