Escalante L, Lopez H, del Carmen Mateos R, Lara F, Sanchez S
J Gen Microbiol. 1982 Sep;128(9):2011-5. doi: 10.1099/00221287-128-9-2011.
The effect of a D-glucose on growth and erythromycin production by Streptomyces erythraeus was investigated. D-Glucose stimulated growth and caused a strong but temporary suppression of antibiotic formation. Maximum specific suppression of erythromycin formation occurred at a carbohydrate concentration of 20 mg ml-1. A non-metabolizable analogue of glucose, 2-deoxy-D-glucose, also suppressed antibiotic formation. Since glucose caused a decrease in erythromycin formation only when added before the stage of antibiotic production, we conclude that this sugar exerted a transient repressive effect on erythromycin biosynthesis.
研究了D-葡萄糖对红色链霉菌生长及红霉素产生的影响。D-葡萄糖刺激生长，并对抗生素形成产生强烈但短暂的抑制作用。红霉素形成的最大特异性抑制出现在碳水化合物浓度为20毫克/毫升时。葡萄糖的一种不可代谢类似物2-脱氧-D-葡萄糖也抑制抗生素形成。由于葡萄糖仅在抗生素产生阶段之前添加时才导致红霉素形成减少，我们得出结论，这种糖对红霉素生物合成产生了短暂的抑制作用。
