胰液对犬基础胰腺和胃液分泌的影响。
Effect of pancreatic juice on basal pancreatic and gastric secretion in dogs.
作者信息
Magee D F, Naruse S
出版信息
J Physiol. 1982 Sep;330:489-96. doi: 10.1113/jphysiol.1982.sp014354.
Abstract
- The effect of duodenal infusion of pancreatic juice on basal pancreatic and gastric secretion was studied in five conscious dogs provided with pancreatic fistulae, gastric fistulae and Heidenhain fundic pouches. 2. Pancreatic juice and trypsin stimulated a pancreatic secretion rich in protein. 3. Autodigested juice without proteolytic activities also stimulated the secretion. Boiling the juice or addition of trypsin inhibitor to the juice diminished the augmented secretion. 4. It seems, therefore, that trypsin is necessary even in proteolytically inactive autodigested juice for pancreatic stimulation. 5. In dogs, unlike rats and pigs, basal pancreatic secretion is not under negative feed-back control by duodenal tryptic activity. 6. Basal gastric secretion was not significantly changed by duodenal infusion of pancreatic juice.
摘要
- 在五只装有胰瘘、胃瘘和海登海因胃底小囊的清醒犬中，研究了十二指肠注入胰液对基础胰腺和胃分泌的影响。2. 胰液和胰蛋白酶刺激了富含蛋白质的胰腺分泌。3. 无蛋白水解活性的自消化胰液也刺激了分泌。将胰液煮沸或向胰液中添加胰蛋白酶抑制剂可减少增强的分泌。4. 因此，似乎即使在无蛋白水解活性的自消化胰液中，胰蛋白酶对于胰腺刺激也是必需的。5. 在犬中，与大鼠和猪不同，基础胰腺分泌不受十二指肠胰蛋白酶活性的负反馈控制。6. 十二指肠注入胰液对基础胃分泌没有显著影响。
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