胃分泌在清醒大鼠旷置术后胰腺高分泌中的作用。
The role of gastric secretion in post-diverted pancreatic hypersecretion in conscious rats.
作者信息
Noda A, Magee D F, Sarles H
出版信息
J Physiol. 1982 May;326:453-9. doi: 10.1113/jphysiol.1982.sp014205.
Abstract
- In rats prepared with chronic external pancreatic fistulae, gastric fistulae and choledocho-enterostomy, the volume and protein secretion of pancreatic juice was measured. 2. The pancreatic secretion of water and protein after juice diversion was significantly lower when the gastric fistula was open than when closed. Secretion was abolished after atropine, with the fistula open and in animals with ligated pylori. 3. Intraduodenal HCl significantly raised juice volume and protein in animals with diverted juice when the gastric fistula was open. 4. Soybean trypsin inhibitor produced a significantly smaller elevation of juice volume and protein when the gastric fistula was open. 5. It is concluded that the initial hypersecretion of pancreatic juice and protein, following its diversion from the duodenum, is a consequence of the entry of gastric juice into the intestine.
摘要
- 在制备了慢性外部胰瘘、胃瘘和胆总管肠吻合术的大鼠中，测量了胰液的体积和蛋白质分泌量。2. 当胃瘘开放时，胰液引流后胰液中水和蛋白质的分泌量显著低于胃瘘关闭时。在阿托品作用下、胃瘘开放时以及幽门结扎的动物中，分泌被消除。3. 当胃瘘开放时，十二指肠内盐酸显著增加了胰液引流动物的胰液体积和蛋白质含量。4. 当胃瘘开放时，大豆胰蛋白酶抑制剂使胰液体积和蛋白质的增加量显著减小。5. 得出的结论是，胰液从十二指肠转流后最初的高分泌是胃液进入肠道的结果。
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