Anashkin O D, Beliaev S M
Kosm Biol Aviakosm Med. 1982 Nov-Dec;16(6):28-31.
To study physiological effects of weightlessness, 12 male volunteers, aged 25-33, were exposed to 7-day water immersion. The test subjects were divided into two groups of 6 in each: the first group subjects were given a new Soviet stimulant sydnocarb (3-(beta-phenylisopropyl) -N-phenyl carbamoyl sydnonimine) and the second group subjects were given a placebo, using the double-blind method. To evaluate the cardiorespiratory function, the test subjects exercised on a bicycle ergometer before and after water immersion. During exercises ECG, heart rate, minute respiration volume, oxygen consumption, carbon dioxide production, cardiac output, oxygen pulse were recorded. The test subjects on the placebo showed a significant decrease of oxygen consumption at at maximum workload. Those who were given sydnocarb maintained normal oxygen consumption during bicycle ergometry. The drug increased the workload per kg body weight, maintained physical work capacity, and improved the cardiovascular function after immersion.
为研究失重的生理效应，12名年龄在25至33岁之间的男性志愿者接受了为期7天的水浸试验。试验对象被分为两组，每组6人：第一组对象服用一种新的苏联兴奋剂西地卡（3-（β-苯异丙基）-N-苯基氨基甲酰西多尼明），第二组对象服用安慰剂，采用双盲法。为评估心肺功能，试验对象在水浸前后在自行车测力计上进行锻炼。在锻炼过程中，记录心电图、心率、每分钟呼吸量、耗氧量、二氧化碳产生量、心输出量、氧脉搏。服用安慰剂的试验对象在最大工作量时耗氧量显著下降。服用西地卡的人在自行车测力计测试期间保持正常耗氧量。该药物增加了每公斤体重的工作量，维持了体力工作能力，并改善了浸水后的心血管功能。
