Lakota N G, Kvasova M M, Larina I M, Vorob'ev D V, Ostrovskaia G Z
Kosm Biol Aviakosm Med. 1990 Mar-Apr;24(2):41-6.
Twenty-one subjects took part in experiments with acute cooling (maximally allowable time for swimming in ice-cold water and two-day exposure to winter field conditions) or two-day exposure to microgravity (simulated by water immersion). They were divided into a placebo group (5, 5 and 6 man-exposures) and a sydnocarb group (6, 6 and 4 man-exposures) and examined by biochemical, radioimmune and radioligand methods. It was found that physiological responses to cold and microgravity effects as well as sydnocarb were similar. During cold exposures the thermal steady-state was achieved by taking maximum daily doses of the drug. In thermoneutral water immersion body temperature fall was controlled by therapeutic doses of the drug. Body temperature decline beginning with immersion day 2 can be related to the endogenous decline of heat production due to a new functioning level which is well known in gravitational physiology, i. e. this is the effect of microgravity per se. With respect to old and new information about the pharmacological properties of sydnocarb, mechanisms of its high thermoregulatory effects on CNS structures responsible for heat production and heat loss are discussed.
21名受试者参与了急性降温实验（在冰冷水中游泳的最大允许时间以及在冬季野外条件下暴露两天）或两天的微重力暴露实验（通过水浸模拟）。他们被分为安慰剂组（5、5和6人次暴露）和辛诺卡（sydnocarb）组（6、6和4人次暴露），并通过生化、放射免疫和放射性配体方法进行检查。结果发现，对寒冷、微重力效应以及辛诺卡的生理反应相似。在寒冷暴露期间，通过服用最大日剂量的药物达到热稳态。在热中性水浸中，体温下降由药物的治疗剂量控制。从浸泡第2天开始的体温下降可能与由于重力生理学中已知的新功能水平导致的内源性产热下降有关，也就是说，这是微重力本身的作用。关于辛诺卡药理特性的新旧信息，讨论了其对负责产热和散热的中枢神经系统结构具有高热调节作用的机制。
