Koréh K, Seligman M L, Demopoulos H B
Lipids. 1982 Oct;17(10):724-6. doi: 10.1007/BF02534658.
Dihydroergotoxine mesylate (DHET), an ergot alkaloid derivative, is widely used to treat senile cerebral vascular insufficiency. Aspects of this age-related phenomenon may be due to deterioration by lipid oxidation of cellular membranes. DHET stabilizes EEG alpha frequencies, increases cerebral blood flow and oxygen uptake and accumulates in lipid-rich structures of the brain. The effect of DHET was studied on iron-catalyzed peroxidation of liposomes as measured by the thiobarbituric acid assay. It was found that DHET inhibits peroxidation in vitro in a dose-dependent manner. These results suggest that DHET acts in part as a lipid antioxidant when used to treat senile cerebral vascular insufficiency.
甲磺酸双氢麦角毒碱（DHET）是一种麦角生物碱衍生物，广泛用于治疗老年脑血管功能不全。这种与年龄相关现象的某些方面可能是由于细胞膜脂质氧化导致的恶化。DHET可稳定脑电图α频率，增加脑血流量和氧摄取，并在大脑富含脂质的结构中蓄积。通过硫代巴比妥酸测定法研究了DHET对脂质体铁催化过氧化作用的影响。结果发现，DHET在体外以剂量依赖方式抑制过氧化作用。这些结果表明，DHET在用于治疗老年脑血管功能不全时部分发挥脂质抗氧化剂的作用。
