Volmer J
Liver. 1982 Jun;2(2):82-94. doi: 10.1111/j.1600-0676.1982.tb00183.x.
Morphometric investigations were carried out on liver biopsies of chronic aggressive (active) hepatitis (CAH), type IIa, chronic aggressive (active) hepatitis, type IIb, and on chronic nonsuppurative destructive cholangitis (CNDC) (primary biliary cirrhosis (PBC) in the second and third stages. The goal of the histometric analysis was a comparison of the portal tracts before and after immunosuppressive therapy with azathioprine and corticosteroids as well as with azathioprine alone. The volume and surface measurements of the portal tracts and their components showed that for an evaluation of the effectivity of the immunosuppressive therapy on CAH, along with a division into HBsAg-positive and -negative cases, a histologically determined degree of the severity of the inflammatory activity is extremely significant. The therapeutic effect is significant for all cases of CAH IIb, evident for HBsAg-negative cases of CAH IIa and slight for HBsAg-positive cases of CAH IIa. Immunosuppressive therapy of CNDC has no effect on the characteristic destruction process of the bile ducts and ductule proliferation.
对IIa型慢性侵袭性（活动性）肝炎、IIb型慢性侵袭性（活动性）肝炎以及慢性非化脓性破坏性胆管炎（CNDC）（第二和第三阶段的原发性胆汁性肝硬化（PBC））的肝活检进行了形态计量学研究。组织计量学分析的目的是比较使用硫唑嘌呤和皮质类固醇进行免疫抑制治疗前后以及仅使用硫唑嘌呤治疗前后的门管区情况。门管区及其组成部分的体积和表面积测量结果表明，为了评估免疫抑制治疗对慢性侵袭性肝炎的有效性，除了将病例分为乙肝表面抗原（HBsAg）阳性和阴性外，组织学确定的炎症活动严重程度也极为重要。对于所有IIb型慢性侵袭性肝炎病例，治疗效果显著；对于IIa型慢性侵袭性肝炎的HBsAg阴性病例，治疗效果明显；而对于IIa型慢性侵袭性肝炎的HBsAg阳性病例，治疗效果轻微。慢性非化脓性破坏性胆管炎的免疫抑制治疗对胆管的特征性破坏过程和小胆管增生没有影响。
