4种DNA嵌入剂在L5178Y小鼠淋巴瘤细胞中的比较致突变性。
Comparative mutagenicity of 4 DNA-intercalating agents in L5178Y mouse lymphoma cells.
作者信息
Rogers A M, Back K C
出版信息
Mutat Res. 1982 Dec;102(4):447-55. doi: 10.1016/0165-1218(82)90107-0.
The mutagenicity of 4 known intercalating agents acridine orange (AO), quinacrine mustard (QM), proflavin (PF) and ethidium bromide (EB) has been investigated in L5178Y mouse lymphoma cells. Methyl methanesulfonate (MMS) was used as a positive control in these studies. AO, QM and PF induced mutation in the excess thymidine- and thioguanine-selective systems. These 3 compounds were negative in the ouabain- and cytosine-arabinoside-selective systems while EB was positive only in the cytosine arabinoside system. It would appear that the EB-induced mutagenesis is different from that of AO, QM and PF though all are intercalating agents. Since the molecular origin of cytosine arabinoside mutants is unknown, further interpretation of the EB results is not possible.
已在L5178Y小鼠淋巴瘤细胞中研究了4种已知嵌入剂吖啶橙（AO）、喹吖因氮芥（QM）、原黄素（PF）和溴化乙锭（EB）的致突变性。在这些研究中，甲磺酸甲酯（MMS）用作阳性对照。AO、QM和PF在过量胸苷和硫鸟嘌呤选择系统中诱导突变。这3种化合物在哇巴因和阿糖胞苷选择系统中呈阴性，而EB仅在阿糖胞苷系统中呈阳性。尽管所有这些都是嵌入剂，但EB诱导的诱变似乎与AO、QM和PF不同。由于阿糖胞苷突变体的分子起源尚不清楚，因此无法对EB的结果进行进一步解释。
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