Sutton J V, Brown C, Adler A J, Feinroth M, Feinroth M V, Friedman E A, Berlyne G M
Nephron. 1982;32(2):108-12. doi: 10.1159/000182828.
In 11 patients suffering from nephrotic syndrome, renal phosphate handling was studied in water immersion up to the neck. There was a rapid onset of phosphate diuresis which continued to increase throughout water immersion; and an increase in fractional excretion of phosphate (FEPO4) continuing throughout immersion and decreasing in the hour after immersion. TmPO4/GFR did not change on immersion. TmPO4/Inulin clearance gave higher figures than TmPO4/creatinine clearance due to secretion of creatinine in 9 of 11 patients. There was a transitory increase in PTH during immersion, but mean immersion plasma levels of PTH did not change when compared to preimmersion control values. FEPO4 was more frequently significantly correlated with FECL than to FENa in nephrotics.
对11例肾病综合征患者进行了研究，观察其在颈部以下水浸状态下的肾脏磷酸盐处理情况。磷酸盐利尿迅速出现，且在整个水浸过程中持续增加；磷酸盐排泄分数（FEPO4）在整个水浸过程中持续增加，在水浸后1小时下降。TmPO4/GFR在水浸时无变化。由于11例患者中有9例存在肌酐分泌，TmPO4/菊粉清除率的数值高于TmPO4/肌酐清除率。水浸过程中甲状旁腺激素（PTH）有短暂升高，但与浸前对照值相比，浸浴期间PTH的平均血浆水平无变化。在肾病患者中，FEPO4与FECL的相关性比与FENa的相关性更常见且显著。
