Gallo P V, Weinberg J
Neurobehav Toxicol Teratol. 1982 Sep-Oct;4(5):505-13.
Pregnant rats were given liquid diet with ethanol ad lib, liquid control diet pair-fed to Group 1, or pelleted control diet ad lib. No differences were found in offspring birth weight or rate of growth over 5 postnatal weeks. Upper and lower incisors erupted earlier and palmar grasp disappeared earlier in pair-fed and alcohol animals, while all groups were alike in eye opening, ear unfolding, negative geotaxis, auditory startle, surface righting, cliff avoidance, free-fall righting and mesh climbing. However, ethanol exposed animals showed deficits in orienting ability at 2-7 days of age and in response inhibition in a punished step-down task at 35 days of age. Furthermore, preweaning handling eliminated the deficit in response inhibition. Taken together, these data indicate that without the confounding variable of undernutrition, prenatal ethanol exposure may differentially affects the development of systems involving sensory perception, motivation or inhibition, while systems involving physical, reflex, and locomotor development remain unaltered.
给怀孕大鼠随意喂食含乙醇的流质饮食、与第1组配对喂食的流质对照饮食或随意喂食的颗粒状对照饮食。在产后5周内，未发现后代出生体重或生长速率存在差异。在配对喂食和摄入酒精的动物中，上下门齿萌出较早，手掌抓握消失较早，而在睁眼、耳朵展开、负趋地性、听觉惊吓、表面翻正、悬崖回避、自由落体翻正和网格攀爬方面，所有组都是相似的。然而，暴露于乙醇的动物在2至7日龄时定向能力存在缺陷，在35日龄时的惩罚性阶梯下行任务中反应抑制存在缺陷。此外，断奶前的处理消除了反应抑制方面的缺陷。综上所述，这些数据表明，在没有营养不良这个混杂变量的情况下，产前乙醇暴露可能会对涉及感官知觉、动机或抑制的系统发育产生不同影响，而涉及身体、反射和运动发育的系统则保持不变。
