Ishikawa M, Handa H, Maeda A, Koshikawa T, Kitazawa S, Hori R
No Shinkei Geka. 1982 Oct;10(10):1077-83.
In the neurosurgical care, postoperative convulsion, the especially in the early postoperative course, is one of major complications because it can spoil an otherwise good surgical result. The present study was intended to investigate the prophylactic use of anticonvulsants on chemical measurement of their plasma levels. Parenteral diphenylhydantoin (DPH) given just before craniotomy failed to maintain high level of DPH in the postoperative course even with pretreatment of oral DPH. On the other hand, preoperative oral phenobarbital administration maintained fairly high level in spite of no prescription on the operative day. Intravenous DPH of 250 mg immediately after craniotomy resulted in fairly high level of DPH throughout the early postoperative course in cases of pretreatment of oral DPH. In reviewing the pharmacokinetics of anticonvulsants, the prophylactic use of anticonvulsants in the early postoperative course was discussed.
在神经外科护理中，术后惊厥，尤其是在术后早期，是主要并发症之一，因为它可能会破坏原本良好的手术效果。本研究旨在探讨抗惊厥药物的预防性使用及其血浆水平的化学测定。即使术前口服苯妥英钠进行预处理，开颅手术前静脉注射苯妥英钠（DPH）也无法在术后维持较高的DPH水平。另一方面，尽管手术当天未给药，但术前口服苯巴比妥能维持相当高的水平。对于术前口服DPH预处理的病例，开颅术后立即静脉注射250mg DPH可在术后早期维持相当高的DPH水平。在回顾抗惊厥药物的药代动力学时，讨论了术后早期抗惊厥药物的预防性使用。
