Tsankov Iu, Iordanova I, Lolova D, Uzunova S, Dinoeva S
Probl Khig. 1982;7:127-36.
Heavy metals /lead and copper/ content was studied in various cosmetic articles: creams and cleansing milk, shampoos, hair dyes, eye shadows, rouge, lipsticks, powders, fond de teint, tooth pastes. The method flame atom-absorption spectrometry with chelation and extraction was used for their determination. The subacute dermal toxicity on albino rats was studied with working doses: lead--1,10 and 100 mg/kg, and copper--5,50 and 500 mg/kg. The content of lead and copper was established to be low in the majority of the cosmetic articles studied /lead--to 2.08 mg/kg, copper--to 6,28 mg/kg/and only in some of the articles of decorative cosmetic, it is considerably higher /lead--to 41,1 mg/kg, copper--to 138,6 mg/kg. That is due to the inadequate purification of the initial raw materials or to the presence of copper-containing dyes in the composition of the respective cosmetic article. As a result from the toxicological and pathoanatomical studies the small doses /lead 1 mg/kg and copper 5 mg/kg are defined as ineffective, and the high doses--with a light biological effect. The maximum allowable concentration of lead is proposed to be--10 mg/kg, and copper--50 mg/kg as side /technical/ pollutants in the production of cosmetic articles.
对各类化妆品中的重金属（铅和铜）含量进行了研究，这些化妆品包括面霜、洁面乳、洗发水、染发剂、眼影、胭脂、口红、粉饼、粉底、牙膏。采用螯合萃取火焰原子吸收光谱法对其进行测定。以铅1、10和100毫克/千克以及铜5、50和500毫克/千克的工作剂量对白化大鼠进行了亚急性皮肤毒性研究。在所研究的大多数化妆品中，铅和铜的含量较低（铅含量达2.08毫克/千克，铜含量达6.28毫克/千克），只有某些装饰性化妆品中的含量相当高（铅含量达41.1毫克/千克，铜含量达138.6毫克/千克）。这是由于初始原料净化不充分或相应化妆品成分中含有含铜染料所致。毒理学和病理解剖学研究结果表明，小剂量（铅1毫克/千克和铜5毫克/千克）被确定为无效，高剂量具有轻微生物学效应。建议将铅的最大允许浓度设定为10毫克/千克，铜的最大允许浓度设定为50毫克/千克，作为化妆品生产中的次要（技术）污染物。
