Bressler R S, Lustbader I J
Andrologia. 1978 Jul-Aug;10(4):291-8. doi: 10.1111/j.1439-0272.1978.tb03035.x.
Although systemically administered testosterone can effect the postnatal maturation of elements in the seminiferous tubule in hypophysectomized rats and mice, it does not elicit the same degree of development which occurs in normal control animals. In view of reports of precocious spermatogenesis in androgen secreting Leydig cell tumors, the present study was designed to determine if high local levels of testosterone accelerate development of the seminiferous tubules. Testosterone pellets were inserted under the tunica albuginea of the right testis of 7 day old rats. At 17, 23 and 28 days of age development of the seminiferous tubules, as judged by the formation of tubule lumens, was more extensive in the treated testes than in contralateral and sham operated controls. Tubule diameters were not necessarily correlated with lumen formation. This study demonstrates that high local levels of testosterone accelerate seminiferous tubule development in the rat and indicates that tubule diameter may not be a valid basis for estimating development of the testis. It is suggested that testosterone exerts this effect through its actions on the Sertoli cells.
虽然经全身给药的睾酮可影响垂体切除的大鼠和小鼠生精小管内各成分的出生后成熟，但它所引发的发育程度与正常对照动物并不相同。鉴于有报告称雄激素分泌性睾丸间质细胞瘤中存在早熟精子发生，本研究旨在确定局部高浓度睾酮是否会加速生精小管的发育。将睾酮丸剂植入7日龄大鼠右侧睾丸的白膜下。在17日龄、23日龄和28日龄时，根据管腔形成判断，处理侧睾丸中生精小管的发育比同侧及假手术对照更为广泛。小管直径不一定与管腔形成相关。本研究表明，局部高浓度睾酮可加速大鼠生精小管的发育，并表明小管直径可能不是评估睾丸发育的有效依据。提示睾酮通过对支持细胞的作用发挥此效应。
