Comparative lethality of coca and cocaine.
作者信息
Bedford J A, Turner C E, Elsohly H N
出版信息
Pharmacol Biochem Behav. 1982 Nov;17(5):1087-8. doi: 10.1016/0091-3057(82)90499-3.
PMID:7178201
Abstract
The 24 hour lethal effects of cocaine were compared to those of a crude ethanol extract of the coca leaf (Erthroxylon coca) in male, Swiss mice. Various doses of cocaine HCl and coca leaf extracts suspended in a Tween 60, Arlacel 83, and distilled water vehicle were injected IP into groups of 10 mice. The LD50 for cocaine was 95.1 mg/kg. The LD50 for the coca extract was 3450 mg/kg. The LD50 of the extract based on its cocaine content was 31.4 mg/kg. The results clearly indicate that the coca leaf contains constituents other than cocaine that can contribute to a toxic effect of the plant.
摘要
相似文献
1
Comparative lethality of coca and cocaine.
Pharmacol Biochem Behav. 1982 Nov;17(5):1087-8. doi: 10.1016/0091-3057(82)90499-3.
2
Comparative stimulus properties of two fractions of the coca leaf (E. coca).
Pharmacol Biochem Behav. 1981 Dec;15(6):907-9. doi: 10.1016/0091-3057(81)90052-6.
3
Anorexic activity of cocaine and coca extract in naive and cocaine tolerant rats.
Pharmacol Biochem Behav. 1983 Apr;18(4):515-7. doi: 10.1016/0091-3057(83)90273-3.
4
Local anesthetic effects of cocaine and several extracts of the coca leaf (E. coca).
Pharmacol Biochem Behav. 1984 May;20(5):819-21. doi: 10.1016/0091-3057(84)90207-7.
5
The anorexic and actometric effects of cocaine and two coca extracts.
Pharmacol Biochem Behav. 1980 Sep;13(3):403-8. doi: 10.1016/0091-3057(80)90246-4.
6
Constituents in Erythroxylum coca I: gas chromatographic analysis of cocaine from three locations in Peru.古柯叶中的成分I：秘鲁三个地区可卡因的气相色谱分析
Bull Narc. 1979 Jan-Mar;31(1):71-6.
7
Analysis of alkaloids in leaves of cultivated Erythroxylum and characterization of alkaline substances used during coca chewing.栽培古柯叶中生物碱的分析及古柯咀嚼过程中所用碱性物质的表征
J Ethnopharmacol. 1981 Mar-May;3(2-3):313-35. doi: 10.1016/0378-8741(81)90061-1.
8
Coca leaf as a therapeutic agent.古柯叶作为一种治疗剂。
Am J Drug Alcohol Abuse. 1978;5(1):75-86. doi: 10.3109/00952997809029262.
9
Evaluation of a fiber optic immunosensor for quantitating cocaine in coca leaf extracts.
Biosens Bioelectron. 1997;12(2):113-24. doi: 10.1016/s0956-5663(97)87057-1.
10
Topics in the chemistry of cocaine.可卡因化学专题
Bull Narc. 1985 Jan-Mar;37(1):63-78.
引用本文的文献
1
DARK Classics in Chemical Neuroscience: Cocaine.化学神经科学经典系列：可卡因。
ACS Chem Neurosci. 2018 Oct 17;9(10):2358-2372. doi: 10.1021/acschemneuro.8b00117. Epub 2018 Apr 24.
2
Long-acting cocaine hydrolase for addiction therapy.用于成瘾治疗的长效可卡因水解酶。
Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):422-7. doi: 10.1073/pnas.1517713113. Epub 2015 Dec 28.
3
Immunopharmacotherapeutic manifolds and modulation of cocaine overdose.免疫药理学治疗方法与可卡因过量的调制。
Pharmacol Biochem Behav. 2011 May;98(3):474-84. doi: 10.1016/j.pbb.2011.02.020. Epub 2011 Feb 26.
4
The effect of amiodarone pretreatment on survival of mice with cocaine toxicity.胺碘酮预处理对可卡因中毒小鼠存活率的影响。
J Med Toxicol. 2005 Dec;1(1):11-8. doi: 10.1007/BF03160899.
Zotero 插件