化学神经科学经典系列：可卡因。
DARK Classics in Chemical Neuroscience: Cocaine.
机构信息
Department of Radiology , University of Michigan Medical School , Ann Arbor , Michigan 48109 , United States.
Department of Medicinal Chemistry , University of Michigan , Ann Arbor , Michigan 48105 , United States.
出版信息
ACS Chem Neurosci. 2018 Oct 17;9(10):2358-2372. doi: 10.1021/acschemneuro.8b00117. Epub 2018 Apr 24.
Abstract
In this Review, we consider the story of cocaine from its humble origins in South America to its status as one of the most abused substances in 21st century society. The synthesis and biosynthesis of cocaine are discussed, as well as its pharmacokinetics, metabolism, pharmacology, and importance in modern neuroscience and molecular imaging.
摘要
在这篇综述中，我们回顾了可卡因从古至今的发展历程，从它在南美洲的起源到成为 21 世纪社会中最滥用的物质之一。本文讨论了可卡因的合成和生物合成，以及它的药代动力学、代谢、药理学，以及在现代神经科学和分子成像中的重要性。
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本文引用的文献
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3
Drug-related celebrity deaths: A cross-sectional study.与药物相关的名人死亡：一项横断面研究。
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