在维生素B12缺乏症的治疗过程中，钴胺素在血浆和组织中形成。

Cobalamin forms in plasma and tissue during treatment of vitamin B12 deficiency.

作者信息

Gimsing P, Hippe E, Helleberg-Rasmussen I, Moesgaard M, Nielsen J L, Bastrup-Madsen P, Berlin R, Hansen T

出版信息

Scand J Haematol. 1982 Oct;29(4):311-8. doi: 10.1111/j.1600-0609.1982.tb00600.x.

DOI:10.1111/j.1600-0609.1982.tb00600.x

Abstract

Thin-layer chromatography and bioautography were used to study the cobalamin pattern of plasma, erythrocytes, and hepatic tissue from patients with cobalamin deficiency on maintenance therapy with hydroxocobalamin (Vibeden), a cyanocobalamin depot preparation (Betolvex), or cyanocobalamin tablets (Behepan). The cobalamin pattern in plasma is dominated by the form in which it is administered. The results of assaying the erythrocytes and liver biopsies show that the cobalamins administered are converted to the coenzyme forms in vivo, irrespective of the type of cobalamin preparation.

摘要

采用薄层色谱法和生物自显影法，研究了接受羟钴胺（维伯丁）、氰钴胺长效制剂（倍托维克斯）或氰钴胺片（贝赫潘）维持治疗的钴胺素缺乏患者血浆、红细胞和肝组织中的钴胺素模式。血浆中的钴胺素模式以给药形式为主导。红细胞和肝活检的检测结果表明，无论钴胺素制剂类型如何，给药的钴胺素在体内都会转化为辅酶形式。