Alonso J M, Mazigh D, Bercovier H, Mollaret H H
Ann Microbiol (Paris). 1978 Jul;129B(1):27-36.
Intravenous infection of Swiss mice with a strain of Yersinia enterocolitica unable to colonize normal mice by the oral route, induced a systemic infection. Viable bacteria were isolated from homogenates of liver, spleen and lungs, as early as one hour after the challenge and have been detected during two weeks. On the other hand, the number of viable bacteria isolated from the blood has always been very low. Faecal samples permitted the isolation of Y. enterocolitica even after two weeks, while at this time no more bacteria were isolated from the tissues. The duration of the infection remained unchanged with an inoculum of 10(3), 10(4) or 10(5) viable bacteria. Depending on the size of the inoculum, liver macroscopic abscesses occurred more or less rapidly after the challenge. These abscesses disappeared spontaneously. A single intravenous injection of cyclophosphamide (200 mg/kg) six days after the challenge was followed by an important rise of the number of bacteria in all the tissues. Comparative studies of intravenously infected athymic (Nude) mice and controls showed a higher number of bacteria in the liver and spleen of the athymic animals.
用一株不能通过口服途径在正常小鼠中定殖的小肠结肠炎耶尔森氏菌对瑞士小鼠进行静脉感染，引发了全身性感染。早在攻击后一小时，就能从肝脏、脾脏和肺的匀浆中分离出活菌，并且在两周内都能检测到。另一方面，从血液中分离出的活菌数量一直非常少。即使在两周后，粪便样本仍能分离出小肠结肠炎耶尔森氏菌，而此时组织中已不再分离到细菌。接种10³、10⁴或10⁵个活菌，感染持续时间不变。根据接种量的大小，攻击后肝脏宏观脓肿或多或少会迅速出现。这些脓肿会自发消失。在攻击后六天单次静脉注射环磷酰胺（200mg/kg），随后所有组织中的细菌数量显著增加。对静脉感染的无胸腺（裸）小鼠和对照进行的比较研究表明，无胸腺动物的肝脏和脾脏中有更多细菌。
