Alonso J M, Bercovier H, Destombes P, Mollaret H H
Ann Microbiol (Paris). 1975 Sep;126(2):187-99.
Amongst the 4,500 strains of our collection of Yersinia enterocolitica usually non-pathogenic for laboratory animals, 5 or 6 strains appeared to be naturally pathogenic for mice. Using these strains and non-pathogenic strains representing more than 90 per cent of human isolates in the world (biotype 4, serotype 0:3, phagocyte VIII; biotype 2, serotype 0:9, phagotype X3), the pathogenicity for cyclophosphamid treated mice and athymic Nude mice has been tested. Highly pathogenic strains killed conventional as well as cyclophosphamid treated mice. Non-pathogenic strains for conventional mice did not show any pathogenicity for cyclophosphamid treated mice (strain IP161 excepted) but killed 30 athymic Nude mice inoculated with 5 x 10(8) and 5 x 10(5) organisms by the oral or intraperitoneal routes. Nude mice infected intragastrically or intraperitoneally showed signs of enteritis and bronchopneumonia followed by a septicemia. Abscesses were found in the liver, the spleen and the ileal wall. The infection of Nude mice with Y. enterocolitica resembles naturally acquired human infection where 2/3 of the cases are enteritis among under 4-year-old children and where septicemia occurs among immunologically deficient adults. The role of T-lymphocytes and of immune functions in Y. enterocolitica infection is discussed through our model.
在我们收集的通常对实验动物无致病性的4500株小肠结肠炎耶尔森氏菌中，有5或6株似乎对小鼠具有天然致病性。使用这些菌株以及代表世界上90%以上人类分离株的非致病菌株（生物型4，血清型0:3，吞噬细胞VIII；生物型2，血清型0:9，吞噬型X3），对环磷酰胺处理的小鼠和无胸腺裸鼠的致病性进行了测试。高致病性菌株杀死了常规小鼠以及环磷酰胺处理的小鼠。对常规小鼠无致病性的菌株对环磷酰胺处理的小鼠（IP161菌株除外）未显示任何致病性，但杀死了30只经口服或腹腔接种5×10⁸和5×10⁵个菌的无胸腺裸鼠。经胃内或腹腔感染的裸鼠出现肠炎和支气管肺炎症状，随后发生败血症。在肝脏、脾脏和回肠壁发现脓肿。小肠结肠炎耶尔森氏菌感染裸鼠类似于自然获得性人类感染，其中2/3的病例是4岁以下儿童的肠炎，免疫功能低下的成年人会发生败血症。通过我们的模型讨论了T淋巴细胞和免疫功能在小肠结肠炎耶尔森氏菌感染中的作用。
