大鼠、仓鼠、豚鼠、正常和过氧化氢酶缺乏小鼠对元素汞的摄取及过氧化氢酶活性
Uptake of elemental mercury and activity of catalase in rat, hamster, guinea-pig, normal and acatalasemic mice.
作者信息
Eide I, Syversen T L
出版信息
Acta Pharmacol Toxicol (Copenh). 1982 Oct;51(4):371-6. doi: 10.1111/j.1600-0773.1982.tb01039.x.
Uptake of elemental mercury after inhalation (3.5 mg/m3) and the activity of catalase in brain, liver, kidney and blood were investigated in rat, hamster, guinea-pig, and normal and acatalasemic mice. The uptake of mercury in the species investigated varied considerably, being highest in the two strains of mice, followed by rat and hamster, and lowest in the guinea-pig. The uptake seemed to be more dependent on pulmonary ventilation than on the activity of catalase. The two strains of mice were exposed to a wide range of mercury concentrations in air (0.002-3.5 mg/m3). The content of mercury in brain, liver and kidney was linearly dependent on the mercury concentration in the air, whereas in blood this relationship was exponential. At the lower concentrations of mercury in the inhaled air, the mercury level in blood was significantly lower, and in kidney higher in the acatalasemic mice compared to the normal ones. In acatalasemic mice the mercury content in liver was higher at all concentrations investigated, whereas in brain no difference between the two strains was found.
在大鼠、仓鼠、豚鼠以及正常和无过氧化氢酶小鼠中，研究了吸入元素汞（3.5毫克/立方米）后汞的摄取情况以及脑、肝、肾和血液中过氧化氢酶的活性。在所研究的物种中，汞的摄取差异很大，在两种小鼠品系中最高，其次是大鼠和仓鼠，在豚鼠中最低。汞的摄取似乎更多地取决于肺通气，而非过氧化氢酶的活性。将两种小鼠品系暴露于空气中广泛的汞浓度范围（0.002 - 3.5毫克/立方米）。脑、肝和肾中的汞含量与空气中的汞浓度呈线性相关，而血液中的这种关系是指数关系。在吸入空气中汞浓度较低时，与正常小鼠相比，无过氧化氢酶小鼠血液中的汞水平显著较低，而肾脏中的汞水平较高。在无过氧化氢酶小鼠中，在所研究的所有浓度下肝脏中的汞含量都较高，而在脑中未发现两种品系之间存在差异。
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